Renner U, Gloddek J, Pereda M P, Arzt E, Stalla G K
Max-Planck-Institute of Psychiatry, Department of Endocrinology, Munich, Germany.
Domest Anim Endocrinol. 1998 Sep;15(5):353-62. doi: 10.1016/s0739-7240(98)00027-7.
Interleukin-6, mainly produced by monocytes and macrophages is known to influence the secretion of anterior pituitary hormones and is, therefore, considered to play an important role in the interaction between the immune system and the endocrine system. However, IL-6 represents not only a lymphocyte message but is also produced within the anterior pituitary. Folliculostellate (FS) cells have been identified as the source of the intrapituitary IL-6 production in the normal pituitary, whereas in pituitary adenomas IL-6 is produced by the tumor cells themselves. The present review summarizes the knowledge about the regulation of the intrapituitary IL-6 synthesis and release in FS cells. Moreover, the possible roles of the intrinsic IL-6 production for function and growth of normal and adenomatous endocrine pituitary cells are discussed.
白细胞介素-6主要由单核细胞和巨噬细胞产生，已知其会影响垂体前叶激素的分泌，因此被认为在免疫系统与内分泌系统的相互作用中发挥重要作用。然而，白细胞介素-6不仅是淋巴细胞的信号分子，也在垂体前叶内产生。在正常垂体中，滤泡星状（FS）细胞已被确定为垂体内部白细胞介素-6产生的来源，而在垂体腺瘤中，白细胞介素-6由肿瘤细胞自身产生。本综述总结了关于FS细胞中垂体内部白细胞介素-6合成与释放调节的知识。此外，还讨论了内源性白细胞介素-6产生对正常和腺瘤性内分泌垂体细胞功能及生长的可能作用。
