Sartin J L, Elsasser T H, Gunter D R, McMahon C D
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849-5518, USA.
Domest Anim Endocrinol. 1998 Sep;15(5):423-9. doi: 10.1016/s0739-7240(98)00022-8.
Disease or endotoxemia alters the plasma concentrations of anabolic hormones, particularly growth hormone (GH) and insulin-like growth-factor I (IGF-I). In general, these hormones are inhibited during the catabolic disease state. A hypothesis has evolved that anabolic hormones might be useful in patients' recovery under these and other catabolic circumstances. The treatment of cattle with GH has provided significant improvement in the physiological response of the animals to the subsequent injection of bacterial lypopolysaccharide (LPS), perhaps via inhibition of tumor necrisis factor (TNF) release. However, this improved response to disease was not observed with animals treated with GH and infected with one of two parasitic organisms, Sarcocystis cruzi or Eimeria bovis. Recent attempts with other anabolic hormones, estradiol and progesterone, have proven remarkably effective in improving the adaptive physiological responses of calves to either E. bovis infection or to the injection of LPS. All animals displayed signs of infection, but the intensity and duration of symptoms were reduced. Although a mechanism is not yet known, there were no effects on TNF; cortisol; the percentages of lymphocytes expressing CD2, 4, or 8 antigens; or the production of antibodies.
疾病或内毒素血症会改变合成代谢激素的血浆浓度，尤其是生长激素（GH）和胰岛素样生长因子I（IGF-I）。一般来说，在分解代谢疾病状态下这些激素会受到抑制。一种假说逐渐形成，即在这些及其他分解代谢情况下，合成代谢激素可能有助于患者康复。用GH治疗牛，可显著改善动物对随后注射细菌脂多糖（LPS）的生理反应，这可能是通过抑制肿瘤坏死因子（TNF）释放实现的。然而，在用GH治疗并感染两种寄生虫之一——克氏肉孢子虫或牛艾美耳球虫的动物中，未观察到这种对疾病的反应改善。最近对其他合成代谢激素——雌二醇和孕酮的试验已证明，它们在改善犊牛对牛艾美耳球虫感染或LPS注射的适应性生理反应方面非常有效。所有动物均表现出感染迹象，但症状的强度和持续时间有所减轻。尽管作用机制尚不清楚，但这些激素对TNF、皮质醇、表达CD2、4或8抗原的淋巴细胞百分比或抗体产生均无影响。
