Moore W F, Bentley R C, Kim K R, Olatidoye B, Gray S R, Robboy S J
Department of Pathology, Duke University Medical Center, North Carolina 27710, USA.
Int J Gynecol Pathol. 1998 Oct;17(4):363-7. doi: 10.1097/00004347-199810000-00011.
Differential staining with cytokeratin (CK)-7 and CK-20, two members of a complex family of proteins in human epithelial cells, proved critical in showing that the extremely well-differentiated goblet-cell (intestinal) mucinous epithelium lining the surface of the endometrium and endocervix in two patients and the fallopian tube in one was identical to that of the coincident appendiceal neoplasms. One of these patients also had a large ovarian tumor that grossly and microscopically resembled a mucinous cystadenoma of borderline malignancy and would have been considered primary except for the CK stains (CK-20 positive and CK-7 negative), which suggested metastasis from the appendix, presumably by a transtubal route.
细胞角蛋白（CK）-7和CK-20是人类上皮细胞中复杂蛋白质家族的两个成员，对其进行鉴别染色，对于证明两名患者子宫内膜和子宫颈表面以及一名患者输卵管内衬的高度分化的杯状细胞（肠型）黏液上皮与同时存在的阑尾肿瘤的上皮相同至关重要。其中一名患者还患有一个大的卵巢肿瘤，大体和显微镜下表现类似于交界性恶性黏液性囊腺瘤，若不是CK染色结果（CK-20阳性、CK-7阴性），该肿瘤可能会被认为是原发性的，这些染色结果提示肿瘤可能是通过输卵管途径从阑尾转移而来。
