作为桥连核苷的前药合成。
Synthesis of prodrugs as bridged nucleosides.
作者信息
Hatlelid J, Benneche T, Undheim K
机构信息
Department of Pharmacy, University of Oslo, Norway.
出版信息
Acta Chem Scand (Cph). 1998 Oct;52(10):1270-4. doi: 10.3891/acta.chem.scand.52-1270.
Abstract
Methods for the preparation of N,N'-connected bisnucleosides have been developed. The bridge is formally a carbonate ester of N-hydroxymethyl nucleosides. Both symmetrical and non-symmetrical bridged bisnucleosides are available.
摘要
已开发出制备N,N'-连接双核苷的方法。该桥正式为N-羟甲基核苷的碳酸酯。对称和非对称桥连双核苷均可得。
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