金硫丁二钠对关节软骨的长期影响。
Long term effects of myochrysine in articular cartilage.
作者信息
Ghadially F N, Lalonde J M
出版信息
Virchows Arch B Cell Pathol. 1978 Jul 14;28(1):31-7. doi: 10.1007/BF02889054.
Intra-articularly administered sodium aurothiomalate (Myochrysine) produced aurosomes containing characteristic electron dense contents (indicating the presence of gold), in the chondrocytes of rabbit articular cartilage. At first the aurosomes were bounded by a membrane but later the electron dense contents were seen lying free in the cytoplasmic matrix. Such deposits were detectable up to 14 months after injection of Myochrysine but none were found at later time intervals (18 months and 2 years). There was a reduction in the population of superficial chondrocytes (Zone I) while those in deeper zones (Zones II and III) showed an increased content of intracytoplasmic filaments. It is thought that these are regressive or degenerative changes produced by gold.
关节内注射硫代苹果酸金钠（金硫葡糖）后，在兔关节软骨的软骨细胞中产生了含有特征性电子致密内容物（表明存在金）的金体。起初，金体被一层膜包围，但后来电子致密内容物可见游离于细胞质基质中。在注射金硫葡糖后长达14个月都可检测到此类沉积物，但在之后的时间间隔（18个月和2年）未发现任何沉积物。表层软骨细胞（I区）数量减少，而较深区域（II区和III区）的细胞胞质内细丝含量增加。据认为，这些是由金产生的退行性或变性变化。
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