唾液羟色胺：猫唾液及下颌下腺中的血管升压物质。
Sialotonin: vasopressor substance in saliva and submandibular gland of the cat.
作者信息
Barton S, Karpinski E, Moriwaki C, Schachter M
出版信息
J Physiol. 1976 Oct;261(3):523-33. doi: 10.1113/jphysiol.1976.sp011572.
Abstract
- The large molecular pressor agent, sialotonin, present in cat saliva, has been separated from kallikrein and characterized further. 2. Sialotonin is present in saliva produced by parasympathetic (ch8da) but not in that produced by sympathetic nerve stimulation. After degenerative preganglionic parasympathetic nerve section, both sialotonin and kallikrein disappear completely, or nearly so. Sympathetic nerve section, however, fails to affect the concentration of these substances in chorda saliva. 3. The sialotonin activity is saliva is unaffected by ligation of Wharton's duct for 3--4 days whereas the kallikrein concentration is greatly reduced. 4. Although normally present in chorda saliva, sialotonin cannot be detected in aqueous extracts of the submandibular gland. It is present, however, in extracts of glands which have previously been subjected to prolonged sympathetic nerve stimulation or to ligation of the duct for 3-4 days. 5. The intravenous or close-aterial injection of sialotonin causes marked but brief reductions of blood flow in the submaxillary gland and intestine.
摘要
- 存在于猫唾液中的大分子升压剂——涎羟色胺，已从激肽释放酶中分离出来并作了进一步鉴定。2. 涎羟色胺存在于由副交感神经（鼓索）产生的唾液中，而不存在于由交感神经刺激产生的唾液中。节前副交感神经变性切断后，涎羟色胺和激肽释放酶都完全消失或几乎完全消失。然而，交感神经切断并不影响鼓索唾液中这些物质的浓度。3. 结扎沃顿管3 - 4天，唾液中的涎羟色胺活性不受影响，而激肽释放酶浓度则大大降低。4. 虽然涎羟色胺通常存在于鼓索唾液中，但在下颌下腺的水提取物中却检测不到。然而，它存在于先前经过长时间交感神经刺激或结扎导管3 - 4天的腺体提取物中。5. 静脉内或动脉内注射涎羟色胺会导致颌下腺和肠道的血流显著但短暂减少。
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引用本文的文献
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Effect of nerve stimulation, denervation, and duct ligation, on kallikrein content and duct cell granules of the cat's submandibular gland.神经刺激、去神经支配和导管结扎对猫下颌下腺激肽释放酶含量及导管细胞颗粒的影响。
Experientia. 1977 Jun 15;33(6):746-8. doi: 10.1007/BF01944167.
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Recent studies on kallikrein in the submandibular gland of the cat [proceedings].猫下颌下腺中激肽释放酶的近期研究[会议论文集]
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J Physiol. 1934 Oct 17;82(3):293-304. doi: 10.1113/jphysiol.1934.sp003182.
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Secretion of kallikrein and its role in vasodilatation in the submaxillary gland.颌下腺中激肽释放酶的分泌及其在血管舒张中的作用。
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6
Sialotonin: vasopressor substance in cat submaxillary saliva.唾液羟色胺：猫下颌下唾液中的血管升压物质。
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