Barton S, Sanders E J, Schachter M, Uddin M
J Physiol. 1975 Oct;251(2):363-9. doi: 10.1113/jphysiol.1975.sp011097.
The parasympathetic and sympathetic nerves to the submandibular gland of the anaesthetized cat were stimulated under specific conditions. 1. It was possible to decrease the kallikrein (kininogenase) content of the gland by as much as 90-95% by sympathetic nerve stimulation. In such a gland the appearance and concentration of secretory granules in the acinar cells were indistinguishable from an unstimulated gland. 2. Parasympathetic nerve stimulation, in contrast to sympathetic nerve stimulation, whilst having no significant effect on the kininogenase content of the gland, resulted in the disappearance of a great majority of the acinar granules. 3. These results demonstrate that the acinar granules in the submandibular gland of the cat are not a significant source of kallikrein. 4. Our experiments also failed to indicate any obvious correlation between the granules of the demilune cells and the kallikrein content of the gland. 5. The possibility is raised that kallikrein is located in the cells of the striated ducts.
在特定条件下，对麻醉猫的下颌下腺的副交感神经和交感神经进行刺激。1. 通过刺激交感神经，有可能使该腺体的激肽释放酶（激肽原酶）含量降低多达90% - 95%。在这样的腺体中，腺泡细胞内分泌颗粒的外观和浓度与未受刺激的腺体并无区别。2. 与交感神经刺激相反，副交感神经刺激虽然对腺体的激肽原酶含量没有显著影响，但导致绝大多数腺泡颗粒消失。3. 这些结果表明，猫下颌下腺中的腺泡颗粒不是激肽释放酶的重要来源。4. 我们的实验也未能表明半月细胞的颗粒与腺体激肽释放酶含量之间存在任何明显的相关性。5. 由此提出一种可能性，即激肽释放酶位于纹状管细胞中。
