Testino G
Department of Gastroenterology and Digestive Endoscopy, San Martino Hospital, Genova, Italy.
Panminerva Med. 1998 Sep;40(3):179-82.
Some authors reported the relationship between Helicobacter pylori (HP) prevalence and gastric cancer incidence. It is generally agreed that HP plays a key role in altering regulatory factors affecting cellular proliferation during the disease process. This hyperproliferation is due, mainly, to active inflammation action on glandular neck cells. Neoplastic changes may arise owing to a loss of control of cell proliferation.
In the present study it has been evaluated the mucopeptic cells (immature cells) expansion in surrounding areas of body-fundic intestinal type advanced gastric cancer (GC) in patients with non atrophic gastritis: the cases have been subdivided in relation with HP infection.
Muco-peptic expansion was present in 73.9% of HP positive GC patients. The cell expansion has not been observed either in HP negative GC or in control subjects.
The phenomenon, a morphological manifestation of hyperproliferation, might overexpose the mucosa to environmental factors. Therefore, in subjects with genetic predisposition, HP could act as a promoter in the progression towards neoplasia independently of chronic atrophic gastritis.
一些作者报道了幽门螺杆菌（HP）感染率与胃癌发病率之间的关系。人们普遍认为，在疾病过程中，HP在改变影响细胞增殖的调节因子方面起关键作用。这种过度增殖主要是由于对腺颈部细胞的活动性炎症作用。由于细胞增殖失控，可能会发生肿瘤性变化。
在本研究中，评估了非萎缩性胃炎患者胃体-胃底肠型进展期胃癌（GC）周围区域的黏液消化细胞（未成熟细胞）扩张情况：根据HP感染情况对病例进行了细分。
73.9%的HP阳性GC患者存在黏液消化细胞扩张。在HP阴性GC患者或对照组中均未观察到细胞扩张。
这种现象是过度增殖的一种形态学表现，可能会使黏膜过度暴露于环境因素。因此，在有遗传易感性的个体中，HP可能独立于慢性萎缩性胃炎，在肿瘤形成的进展中起促进作用。
