Spillantini M G, Goedert M
Department of Neurology, University of Cambridge, UK.
Trends Neurosci. 1998 Oct;21(10):428-33. doi: 10.1016/s0166-2236(98)01337-x.
Abundant tau-positive neurofibrillary lesions constitute a defining neuropathological characteristic of Alzheimer's disease. Filamentous tau pathology is also central to a number of other dementing disorders, such as Pick's disease, progressive supranuclear palsy, corticobasal degeneration and familial frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17). The discovery of mutations in the tau gene in FTDP-17 has firmly established the relevance of tau pathology for the neurodegenerative process. Experimental studies have provided a system for the assembly of full-length tau into Alzheimer-like filaments, providing an assay for the testing of compounds that inhabit the formation of tau filaments.
大量tau蛋白阳性神经原纤维病变是阿尔茨海默病的一个决定性神经病理学特征。丝状tau蛋白病理学也是许多其他痴呆症的核心，如皮克病、进行性核上性麻痹、皮质基底节变性以及与17号染色体相关的家族性额颞叶痴呆和帕金森综合征（FTDP - 17）。FTDP - 17中tau基因突变的发现，坚定地确立了tau蛋白病理学与神经退行性变过程的相关性。实验研究提供了一个将全长tau蛋白组装成阿尔茨海默病样细丝的系统，为测试抑制tau蛋白细丝形成的化合物提供了一种检测方法。
