结直肠癌患者血清白细胞介素-2可溶性受体水平

Levels of serum-soluble receptor for interleukin-2 in patients with colorectal cancer.

作者信息

Saito H, Tsujitani S, Katano K, Ikeguchi M, Maeta M, Kaibara N

机构信息

First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.

出版信息

Surg Today. 1998;28(10):1115-7. doi: 10.1007/BF02483977.

DOI:10.1007/BF02483977

PMID:9786595

Abstract

The preoperative levels of serum-soluble receptor for interleukin-2 (IL-2R) were determined by an enzyme-linked immunosorbent assay in 38 patients undergoing surgery for colorectal cancer and 98 healthy controls. The levels of serum-soluble IL-2R in the patients with colorectal cancer were significantly higher than those in the normal controls (P < 0.05). Markedly elevated levels of serum-soluble IL-2R were recognized in patients with stage IV cancer, those with Dukes' stage D cancer, and those with liver metastasis. Moreover, the prognosis of patients with low levels of IL-2R (<531 U/ml) was significantly better than that of those with high levels (P < 0.05). These findings demonstrate that an elevated concentration of soluble IL-2R might be a useful indicator of liver metastasis and poor prognosis in patients with colorectal carcinoma.

摘要

采用酶联免疫吸附测定法，对38例接受结直肠癌手术的患者及98名健康对照者术前血清白细胞介素-2（IL-2）可溶性受体水平进行了测定。结直肠癌患者血清可溶性IL-2受体水平显著高于正常对照组（P<0.05）。IV期癌症患者、Dukes D期癌症患者及有肝转移的患者血清可溶性IL-2受体水平明显升高。此外，IL-2受体水平低（<531 U/ml）的患者预后明显好于水平高的患者（P<0.05）。这些研究结果表明，可溶性IL-2受体浓度升高可能是结直肠癌患者肝转移及预后不良的一个有用指标。