Baik Yong-Hae, An Ji Yeong, Noh Jae-Hyung, Sohn Tae-Sung, Kim Sung
Department of Surgery, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
J Korean Surg Soc. 2012 Mar;82(3):143-8. doi: 10.4174/jkss.2012.82.3.143. Epub 2012 Feb 27.
Although local resection like endoscopic mucosal resection for early gastric cancer is accepted as a treatment option, one of the most important drawbacks of such an approach is the inability to predictlymph node metastasis. The aim of this study was to evaluate the serum soluble receptor alpha for interleukin-2 (IL-2Rα) level as a predictor of lymph node metastasis in the patients with early gastric cancer.
Assessment of pre-operative serum IL-2Rα levels was performed on 86 patients with early gastric cancer treated by gastrectomies combined with D2 lymph node resections and 20 healthy controls at Samsung Medical Center. Data on patient age and gender, tumor size, depth of invasion, histologic differentiation, and endoscopic findings were reviewed post-operatively. The submucosal lesions were divided into three layers (sm1, sm2, and sm3) in accordance with the depth of invasion.
Lymph node metastasis was observed in 16 patients (18.6%). Statistically, the serum IL-2Rα level was an important predictive factor of lymph node metastasis in undifferentiated gastric cancer, and the cut-off point for the predictive value of serum IL-2Rα level was 200 U/mL.
The serum IL-2Rα level might be a good predictor of lymph node metastasis in undifferentiated early gastric cancer.
尽管像内镜黏膜切除术这样的局部切除被认为是早期胃癌的一种治疗选择，但这种方法最重要的缺点之一是无法预测淋巴结转移。本研究的目的是评估血清可溶性白细胞介素-2受体α（IL-2Rα）水平作为早期胃癌患者淋巴结转移的预测指标。
对三星医疗中心86例行胃切除术联合D2淋巴结清扫术的早期胃癌患者及20名健康对照者进行术前血清IL-2Rα水平评估。术后回顾患者的年龄、性别、肿瘤大小、浸润深度、组织学分化及内镜检查结果。根据浸润深度将黏膜下病变分为三层（sm1、sm2和sm3）。
16例患者（18.6%）出现淋巴结转移。统计学上，血清IL-2Rα水平是未分化型胃癌淋巴结转移的重要预测因素，血清IL-2Rα水平预测值的截断点为200 U/mL。
血清IL-2Rα水平可能是未分化型早期胃癌淋巴结转移的良好预测指标。
