F-腱蛋白在受损周围神经中的积累促进感觉轴突的生长。
Accumulation of F-spondin in injured peripheral nerve promotes the outgrowth of sensory axons.
作者信息
Burstyn-Cohen T, Frumkin A, Xu Y T, Scherer S S, Klar A
机构信息
Department of Anatomy and Cell Biology, The Hebrew University-Hadassah Medical School, Jerusalem, 91120 Israel.
出版信息
J Neurosci. 1998 Nov 1;18(21):8875-85. doi: 10.1523/JNEUROSCI.18-21-08875.1998.
Abstract
F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation of both F-spondin mRNA and protein distal to the lesion. F-spondin in the distal stump of axotomized nerve promotes neurite outgrowth of sensory neurons, as revealed by protein neutralization with F-spondin-specific antibodies. Thus, F-spondin is likely to play a role in promoting axonal regeneration after nerve injury.
摘要
F-spondin是一种细胞外基质蛋白，在胚胎发育期间存在于外周神经中，但出生时其含量会减少。然而，成年大鼠坐骨神经切断术会导致损伤部位远端的F-spondin mRNA和蛋白大量上调。轴突切断神经远端残端中的F-spondin促进感觉神经元的神经突生长，这通过用F-spondin特异性抗体进行蛋白中和得以揭示。因此，F-spondin可能在促进神经损伤后的轴突再生中发挥作用。
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