Krammer P, Taylor B A, Eichmann K
Z Immunitatsforsch Immunobiol. 1978 Jun;154(3):284-95.
A new VH gene is described which governs the expression of idiotypes associated with the antibody response of strain AKR mice to Group A streptococcal carbohydrate (A-CHO). This VH gene, termed ACHd, is identified using guinea pig antisera to a pool of strain AKR antibodies to A-CHO. The genetic polymorphism is revealed by quantitative differences in idiotype expression between different inbred strains. In recombinant inbred strains linkage to the Ig-1d allotype allele of strain AKR is demonstrated. In a putative recombinant strain it appears that ACHd maps at a locus different from that of A5A+, another VH gene controlling idiotypes of anti-A-CHO antibodies. This represents a further example of pseudoallelism between related VH genes and lack of homology in the VH chromosomal region. Expression of the ACHd gene was independent of the Ly-2, 3 locus which is associated with kappa chain variants.
描述了一个新的VH基因，它控制与AKR品系小鼠对A组链球菌碳水化合物（A-CHO）的抗体反应相关的独特型的表达。这个被称为ACHd的VH基因是用豚鼠抗血清针对AKR品系针对A-CHO的一组抗体鉴定出来的。通过不同近交系之间独特型表达的定量差异揭示了遗传多态性。在重组近交系中，证明了与AKR品系的Ig-1d同种异型等位基因存在连锁关系。在一个假定的重组品系中，ACHd似乎定位在与另一个控制抗A-CHO抗体独特型的VH基因A5A+不同的位点。这代表了相关VH基因之间拟等位基因现象的又一个例子，以及VH染色体区域缺乏同源性。ACHd基因的表达独立于与κ链变体相关的Ly-2、3位点。
