Berek C, Taylor B A, Eichmann K
J Exp Med. 1976 Nov 2;144(5):1164-74. doi: 10.1084/jem.144.5.1164.
A small proportion of the antibodies to Group A streptococcal carbohydrate (A-CHO) elicited in BALB/c mice by immunization with Group A streptococci, has idiotypic determinants in common with the BALB/c myeloma protein S117 which has specificity for N-acetyl-glucosamine, the major antigenic determinant of A-CHO. The expression of these idiotypic determinants is under the control of a gene which is linked to the Ig-1a+ allotype locus in strain BALB/c and in other strains carrying the same Ig-1 haplotype. This gene (S117+) segregates in breeding experiments as if it were an allele to the gene A5A+ which controls the expression of the A5A idiotype in association with antibodies to A-CHO in strain A/J and which is linked to the Ig-1e allotype locus. Another possible allele, linked to the Ig-1c allotype locus, controls the expression of both S117 and A5A cross-reactive determinants (S117cr, A5Acr). The distribution of these idiotypic determinants in various lines that carry recombinant Ig-1 haplotypes suggests that the A5A and S117 loci are nonallelic and map at different positions in the Ig-1 region. The data suggest complex pseudollelic relationships between different Ig-1 haplotypes that allow the expression of the same genes in allelic and in nonallelic fashion.
用A组链球菌免疫BALB/c小鼠所产生的一小部分抗A组链球菌碳水化合物（A-CHO）抗体，具有与BALB/c骨髓瘤蛋白S117相同的独特型决定簇，S117对N-乙酰葡糖胺具有特异性，N-乙酰葡糖胺是A-CHO的主要抗原决定簇。这些独特型决定簇的表达受一个基因的控制，该基因与BALB/c品系以及携带相同Ig-1单倍型的其他品系中的Ig-1a+同种异型基因座相连。这个基因（S117+）在育种实验中分离，就好像它是A5A+基因的等位基因，A5A+基因在A/J品系中与抗A-CHO抗体相关联，控制A5A独特型的表达，并且与Ig-1e同种异型基因座相连。另一个可能的等位基因与Ig-1c同种异型基因座相连，控制S117和A5A交叉反应决定簇（S117cr、A5Acr）的表达。这些独特型决定簇在携带重组Ig-1单倍型的各种品系中的分布表明，A5A和S117基因座是非等位的，位于Ig-1区域的不同位置。数据表明不同Ig-1单倍型之间存在复杂的拟等位基因关系，使得相同基因能够以等位和非等位方式表达。
