Anisman H, Lacosta S, Kent P, McIntyre D C, Merali Z
Institute of Neurosciences, Carleton University, Ottawa, Ontario.
Stress. 1998 Jul;2(3):209-20. doi: 10.3109/10253899809167284.
The effects of brief stressor exposure on hypothalamic-pituitary-adrenal (HPA) functioning was assessed in two strains of mice shown to be differentially responsive to stressors. Mild stress (1 min of cold swim, 20 C) led to marked elevations of plasma ACTH and corticosterone concentrations in the stress-reactive BALB/cByJ and the stress-resistant C57Bl/6ByJ mice. Moreover, it was observed that the strains differed in basal CRH content within the amygdala and the paraventricullar nucleus (PVN). Within 1 min of cold swim, the CRH changes were detected in these brain regions in BALB/cByJ mice, but were less apparent in C57Bl/6ByJ mice. Following a chronic stressor regimen, the marked elevations of plasma ACTH associated with acute stressors in BALB/cByJ mice were diminished. In contrast, in C57Bl/6ByJ mice in which acute stressors hardly affected ACTH concentrations, the chronic stressor regimen lead to a marked increase of plasma ACTH. Taken together, data indicate that the stress reactivity differences seen in the two strains of mice are not limited to ACTH and corticosterone, but are also detected with respect to CRH within the amygdala and PVN. Furthermore, the suggestion is offered that the reactivity differences in the two strains of mice may have lead to different profiles of ACTH secretagogues and hence the response profile to later acute and chronic stressors differed in these strains of mice.
在两种对压力源反应不同的小鼠品系中，评估了短暂暴露于压力源对下丘脑 - 垂体 - 肾上腺（HPA）功能的影响。轻度压力（在20摄氏度冷水中游泳1分钟）导致应激反应性的BALB/cByJ小鼠和应激抗性的C57Bl/6ByJ小鼠的血浆促肾上腺皮质激素（ACTH）和皮质酮浓度显著升高。此外，观察到这两个品系在杏仁核和室旁核（PVN）内的基础促肾上腺皮质激素释放激素（CRH）含量存在差异。在冷水中游泳1分钟内，在BALB/cByJ小鼠的这些脑区检测到CRH变化，但在C57Bl/6ByJ小鼠中不太明显。在经历慢性压力源方案后，BALB/cByJ小鼠中与急性压力源相关的血浆ACTH显著升高有所减弱。相反，在急性压力源几乎不影响ACTH浓度的C57Bl/6ByJ小鼠中，慢性压力源方案导致血浆ACTH显著增加。综上所述，数据表明在这两种小鼠品系中看到的应激反应差异不仅限于ACTH和皮质酮，在杏仁核和PVN内的CRH方面也能检测到。此外，有人提出这两种小鼠品系的反应性差异可能导致ACTH促分泌素的不同谱，因此这些小鼠品系对后期急性和慢性压力源的反应谱也有所不同。
