Langosch J M, Normann C, Schirrmacher K, Berger M, Walden J
Department of Psychiatry, University of Freiburg, Germany.
Comp Biochem Physiol A Mol Integr Physiol. 1998 Jul;120(3):545-9. doi: 10.1016/s1095-6433(98)10064-8.
Little is known about the mechanisms of action of kava pyrones which are the pharmacological active compounds of the plant Piper methysticum Forst. We investigated the effects of the synthetic kava pyrone (+/-)-kavain on long-term potentiation (LTP) in the CA1-region of guinea pig hippocampal slices. (+/-)-Kavain reduced the amplitudes of extracellular field potential changes evoked by electrical stimulation in a concentration dependent manner. These effects were reversible. In experiments with LTP no changes were found in the presence of (+/-)-kavain. In conclusion, our findings suggest (+/-)-kavain to be an effective drug in modulating excitatory signals in the hippocampus of guinea pigs. Additionally, no alterations on synaptic plasticity in hippocampal neurons for this kava pyrone can be presumed.
对于卡瓦吡喃酮的作用机制了解甚少，卡瓦吡喃酮是植物卡瓦胡椒（Piper methysticum Forst.）的药理活性化合物。我们研究了合成卡瓦吡喃酮（±）-卡瓦因对豚鼠海马切片CA1区长期增强（LTP）的影响。（±）-卡瓦因以浓度依赖的方式降低了电刺激诱发的细胞外场电位变化的幅度。这些作用是可逆的。在LTP实验中，未发现（±）-卡瓦因存在时的变化。总之，我们的研究结果表明（±）-卡瓦因是调节豚鼠海马兴奋性信号的有效药物。此外，可以推测这种卡瓦吡喃酮对海马神经元的突触可塑性没有改变。
