SLC6A4基因座上血清素转运体启动子的功能多态性与情绪障碍
Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders.
作者信息
Ohara K, Nagai M, Tsukamoto T, Tani K, Suzuki Y, Ohara K
机构信息
Department of Psychiatry, Hamamatsu University School of Medicine, Japan.
出版信息
Biol Psychiatry. 1998 Oct 1;44(7):550-4. doi: 10.1016/s0006-3223(98)00112-7.
BACKGROUND
Heils et al found a functional polymorphism in the transcriptional control region upstream of the serotonin transporter gene at the SLC6A4 locus. The transcriptional promoter activity of the short (s) form was less than twice that of the long (l) form of the serotonin transporter promoter gene. In addition, they found individuals with the s form with associated neurotic characteristics (e.g., anxiety, anger, hostility, and depression). The purpose of this study was to determine whether or not there is an association between this functional polymorphism and mood disorders.
METHODS
The l/s polymorphism was studied in 80 patients with mood disorders and 92 control subjects.
RESULTS
There was statistically no difference between mood disorders and healthy controls in either the genotype or the allele frequency. There was statistically no difference between the genotype and subdiagnosis, family history, single/recurrent episodes of depressive disorders, suicide attempts, or the mean age of onset.
CONCLUSIONS
Our results suggest there is no association between the l/s polymorphism of the serotonin transporter gene and mood disorders.
背景
海尔等人在位于SLC6A4位点的血清素转运体基因上游转录控制区发现了一种功能性多态性。血清素转运体启动子基因短（s）型的转录启动子活性不到长（l）型的两倍。此外，他们发现具有s型的个体伴有相关的神经质特征（如焦虑、愤怒、敌意和抑郁）。本研究的目的是确定这种功能性多态性与情绪障碍之间是否存在关联。
方法
对80例情绪障碍患者和92名对照受试者进行了l/s多态性研究。
结果
情绪障碍患者与健康对照在基因型或等位基因频率上均无统计学差异。在基因型与亚诊断、家族史、抑郁障碍的单次/复发发作、自杀未遂或平均发病年龄之间也无统计学差异。
结论
我们的结果表明血清素转运体基因的l/s多态性与情绪障碍之间无关联。
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