Battaglia G, Napier T C
Neuroscience and Aging Institute, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Drug Alcohol Depend. 1998 Sep 1;52(1):41-8. doi: 10.1016/s0376-8716(98)00043-x.
A Chicago City-Wide Mini-Conference on Cocaine and the Amphetamines was held on the 13 May 1996 at Loyola University Chicago. The purpose of the one day symposium was to facilitate the dissemination of recent research findings of investigators in the Chicago area working in drug abuse research. The speakers discussed recent concepts relating to the consequences of the amphetamines and cocaine on different biologic processes including the development of neuronal pathways, adaptational responses to chronic administration and neurotoxicity. Some of the specific areas discussed were: (a) psychostimulant-induced effects on brain serotonin and dopamine systems, (b) amphetamine-induced neurotoxicity, (c) the long-term consequences of prenatal exposure to cocaine, (d) effects of cocaine withdrawal on hormone responses, and (e) mechanisms underlying drug-taking behavior and dependence. The potential clinical consequences of the research findings and how they impact on medications-development and community efforts in dealing with the problems of drug abuse were also discussed. Progress on these issues, which was presented at the First Annual Follow-Up Meeting, held on the 17 July 1997, are also included in this report.
1996年5月13日，一场关于可卡因和苯丙胺的芝加哥全市范围小型会议在芝加哥洛约拉大学举行。为期一天的研讨会旨在促进芝加哥地区从事药物滥用研究的调查人员分享其近期研究成果。发言者们讨论了与苯丙胺和可卡因对不同生物过程的影响相关的最新概念，这些生物过程包括神经元通路的发育、对长期用药的适应性反应以及神经毒性。讨论的一些具体领域包括：（a）精神兴奋剂对大脑血清素和多巴胺系统的影响；（b）苯丙胺引起的神经毒性；（c）产前接触可卡因的长期后果；（d）可卡因戒断对激素反应的影响；以及（e）吸毒行为和成瘾背后的机制。研究结果的潜在临床后果以及它们如何影响药物开发和社区应对药物滥用问题的努力也在会上进行了讨论。本报告还包括在1997年7月17日举行的第一次年度后续会议上所展示的这些问题的进展情况。
