Doll D C, Weiss R B, Evans H
J Urol. 1976 Nov;116(5):675-6. doi: 10.1016/s0022-5347(17)58965-x.
An extragenital metastatic seminoma in a patient with Klinefelter's syndrome is described. The increased incidence of many types of malignancies in patients with this chromosomal abnormality and the increased susceptibility of XXY cells to transformation by oncogenic SV-40 virus are discussed. A relationship is suggested circumstantially by these observations.
本文描述了一例患有克兰费尔特综合征的患者出现的生殖器外转移性精原细胞瘤。文中讨论了患有这种染色体异常的患者中多种恶性肿瘤发病率增加的情况，以及XXY细胞对致癌性SV - 40病毒转化的易感性增加的情况。这些观察结果间接地提示了一种关联。
