一种以存活时间为反应指标的组胺致敏因子生物测定新方法。
A new biological assay method for histamine-sensitizing factor using survival time as a response.
作者信息
Ishida S, Kurokawa M, Asakawa S
出版信息
Jpn J Med Sci Biol. 1976 Jun;29(3):139-50. doi: 10.7883/yoken1952.29.139.
PMID:978834
Abstract
A new biological assay method using survival time of mice as a graded response after histamine challenge has been developed for the histamine-sensitizing factor of pertussis bacilli. The method is relatively precise and reproducible in estimation and fairly sensitive in the validity tests of biological assay. Effect of endotoxin on the estimation by the proposed method was also investigated in case the method is applied to the control test of pertussis vaccine.
摘要
已开发出一种新的生物测定方法，该方法利用组胺激发后小鼠的存活时间作为分级反应，来检测百日咳杆菌的组胺致敏因子。该方法在评估中相对精确且可重复，在生物测定的有效性测试中相当灵敏。在将该方法应用于百日咳疫苗对照试验的情况下，还研究了内毒素对该方法评估的影响。
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