基于小鼠组胺致敏作用的内毒素效价新检测方法。
New test for endotoxin potency based upon histamine sensitization in mice.
作者信息
Bergman R K, Milner K C, Munoz J J
出版信息
Infect Immun. 1977 Nov;18(2):352-5. doi: 10.1128/iai.18.2.352-355.1977.
Abstract
The results of a test of endotoxic potency based upon the development of histamine hypersensitivity in mice were compared with the results obtained by testing the same materials for pyrogenicity in rabbits and lethality for chicken embryos (CELD50). The results of the histamine hypersensitization test (HHT) correlated well with those of the other two tests. The sensitivity of the HHT was about the same as that of the CELD50 assay. The HHT may provide a relatively inexpensive, fast, and reliable assay method for endotoxin laboratories that do not have the facilities for the more elaborate assays.
摘要
基于小鼠组胺超敏反应发展情况的内毒素效价测试结果，与通过对相同材料进行兔热源性测试和鸡胚致死性测试（CELD50）所获得的结果进行了比较。组胺超敏反应测试（HHT）的结果与其他两项测试的结果相关性良好。HHT的灵敏度与CELD50测定法的灵敏度大致相同。对于没有更精密检测设施的内毒素实验室而言，HHT可能提供一种相对廉价、快速且可靠的检测方法。
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