Nishjima Y, Sakai Y
Jpn J Pharmacol. 1976 Jun;26(3):291-300. doi: 10.1254/jjp.26.291.
Electrical activities evoked by tooth pulp stimulation were recorded in the subnucleus caudalis region of the spinal trigeminal nucleus, and the action of fentanyl, a short-acting narcotic, on these activities was investigated in the alpha-cholinergic anesthetized cat. Fentanyl (20 to 40 mug/kg i.v.) depressed the first peak and potentiated the second one of negative potentials evoked by pulp stimulation in the border area betaeen the nucleus proprius (Pr) and the lateral reticular formation (LRF). Neurons, whose responses to pulp stimulation were depressed by fentanyl, were also predominantly localized in this region. Pulp-induced monophasic negative potential and spike discharges in the more ventro-medial portion of the LRF were not affected by fentanyl. The effect of fentanyl on cells in the marginal zone varied from unit to unit. The selective action of fentanyl on neurons in the border area between the Pr and the LRF may partially explain the analgesic action of fentanyl.
在脊髓三叉神经核尾侧亚核区域记录牙髓刺激诱发的电活动，并在α-胆碱能麻醉猫中研究短效麻醉剂芬太尼对这些活动的作用。芬太尼（静脉注射20至40微克/千克）抑制了在固有核（Pr）和外侧网状结构（LRF）之间边界区域牙髓刺激诱发的负电位的第一个峰值，并增强了第二个峰值。对牙髓刺激反应被芬太尼抑制的神经元也主要位于该区域。LRF腹内侧部分的牙髓诱发的单相负电位和锋电位放电不受芬太尼影响。芬太尼对边缘区细胞的作用因细胞而异。芬太尼对Pr和LRF之间边界区域神经元的选择性作用可能部分解释了芬太尼的镇痛作用。
