Kettunen J, Mäkelä A, Miettinen H, Nevalainen T, Heikkilä M, Törmälä P, Rokkanen P
Department of Surgery, Kuopio University Hospital, Finland.
J Biomed Mater Res. 1998 Dec 5;42(3):407-11. doi: 10.1002/(sici)1097-4636(19981205)42:3<407::aid-jbm9>3.0.co;2-n.
A novel composite material with an ultra-high strength and a low elastic modulus called carbon-fiber-reinforced liquid crystalline polymer (LCP/CF) has been developed. We studied the effects of an intramedullary LCP/CF rod on bone in rabbits. A LCP/CF rod of 3.2 mm in diameter and 50 mm in length was introduced into the intramedullary canal of the right femur in ten rabbits weighing an average of 3.6 (3.1-4.2) kg. The follow-up intervals were 3 and 52 weeks. No signs of deformity or osteopenia were seen in the operated femurs in the radiographic, histological, and histomorphometric studies. Histologically, the implant was enclosed by cancellous bone in the metaphyseal area and by a thin cancellous bone cuff in medullary cavity. Bone was able to grow in direct contact with the LCP/CF rod. No signs of degradation of the implants or of adverse tissue reaction were seen. The intramedullary LCP/CF rod had no harmful effects on bone in rabbits. The biocompatibility of the LCP/CF appeared to be good. This novel composite material demonstrates properties that may be useful in orthopedic applications.
一种名为碳纤维增强液晶聚合物（LCP/CF）的具有超高强度和低弹性模量的新型复合材料已被研发出来。我们研究了髓内LCP/CF棒对兔骨的影响。将一根直径3.2毫米、长度50毫米的LCP/CF棒植入十只平均体重为3.6（3.1 - 4.2）千克的兔右股骨的髓腔内。随访间隔为3周和52周。在影像学、组织学和组织形态计量学研究中，手术侧股骨未见畸形或骨质减少的迹象。组织学上，植入物在干骺端区域被松质骨包围，在髓腔内被一层薄的松质骨袖套包围。骨能够与LCP/CF棒直接接触生长。未见植入物降解或不良组织反应的迹象。髓内LCP/CF棒对兔骨无有害影响。LCP/CF的生物相容性似乎良好。这种新型复合材料展现出了在骨科应用中可能有用的特性。
