Milner D A, Hall M, Davis G G, Brissie R M, Robinson C A
University of Alabama at Birmingham, Department of Pathology, USA.
J Anal Toxicol. 1998 Oct;22(6):545-8. doi: 10.1093/jat/22.6.545.
A 53-year-old Caucasian male victim of suicide was suspected of overdose with sertraline and alprazolam after death-scene investigation. The concentration of sertraline, a selective serotonin reuptake inhibitor, was determined by a gas chromatograph with mass selective detection. The concentration of alprazolam, a triazolobenzodiazepine, was determined by high-performance liquid chromatography. The sertraline concentration was reported at 1.0 mg/L in peripheral blood, which is greater than previously reported in other postmortem cases in which death was attributed to a multiple drug overdose. The N-desmethylsertraline concentration was reported at 0.2 mg/L in peripheral blood, which is far less than in other postmortem cases and suggests acute intoxication in this case. The alprazolam concentration was reported at 33 microg/L in heart blood, which is within the therapeutic range. The cause of death was multiple drug intoxication following acute use of sertraline, the manner of death was suicide, and the mechanism of death is an unexplained drug interaction and/or toxicity.
一名53岁的自杀身亡的白人男性在死后现场调查后被怀疑过量服用舍曲林和阿普唑仑。舍曲林是一种选择性5-羟色胺再摄取抑制剂，其浓度通过带质量选择性检测的气相色谱仪测定。阿普唑仑是一种三唑并苯二氮䓬，其浓度通过高效液相色谱法测定。外周血中舍曲林浓度报告为1.0mg/L，高于先前报告的其他因多药过量致死的死后案例。外周血中N-去甲基舍曲林浓度报告为0.2mg/L，远低于其他死后案例，提示该案例为急性中毒。心血中阿普唑仑浓度报告为33μg/L，处于治疗范围内。死亡原因是急性服用舍曲林后的多药中毒，死亡方式为自杀，死亡机制是不明的药物相互作用和/或毒性。
