Hopfner R L, McNeill J R, Gopalakrishnan V
Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Eur J Pharmacol. 1998 Sep 11;357(1):61-5. doi: 10.1016/s0014-2999(98)00535-4.
The effect of oral vanadate treatment on isometric tension responses were examined in aortic rings isolated from obese and lean Zucker rats. Rats from both strains that were either maintained on food ad libitum or pair-fed were included to serve as controls. Higher plasma insulin and glucose levels and exaggerated aortic tension responses to endothelin-1, methoxamine, and KCl observed in obese Zucker rats were normalized in vanadate treated, but not pair-fed, rats. These data suggest that abnormal vascular responses in obese Zucker rats can be normalized by vanadate treatment in a manner at least partly independent of food intake.
在从肥胖和瘦型 Zucker 大鼠分离出的主动脉环中，研究了口服钒酸盐治疗对等长张力反应的影响。两种品系的大鼠，即自由进食或配对喂养的大鼠，均作为对照。肥胖 Zucker 大鼠中观察到的较高血浆胰岛素和葡萄糖水平，以及对内皮素 -1、甲氧明和氯化钾的主动脉张力反应增强，在接受钒酸盐治疗而非配对喂养的大鼠中恢复正常。这些数据表明，肥胖 Zucker 大鼠的异常血管反应可以通过钒酸盐治疗恢复正常，其方式至少部分独立于食物摄入量。
