Shkhvatsabaia I K, Kramer A A, Pavleeva F M, Suvorov Iu I
Kardiologiia. 1976 Jul;16(7):48-56.
The content of total metabolizing sodium was studied in 74 patients with hypertension of different genesis, using the Na24-isotope dilution technique. Among these patients 31 had essential hypertension, 43--symptomatic hypertension (40--renal, and 3--adrenal). In Stage IB and IIA hypertension, a reduction of the level of total metabolizing sodium and its increased urine excretion were found. At late stages of essential hypertension, like in symptomatic renal hypertension, normal levels of total metabolizing sodium were found, or a slight tendency towards its elevation. In cases of adrenal hypertension (Conn's syndrome, pheochromocytoma) the level of total metabolizing sodium is significantly elevated. No correlation was seen between the levels of total metabolizing sodium, and plasma and erythrocytes sodium. The decrease of total metabolizing sodium at early stages of essential hypertension must be an adaptative reaction of the body, which is proved by the increased urine excretion of sodium.
采用钠 - 24同位素稀释技术，对74例不同病因的高血压患者的总代谢钠含量进行了研究。这些患者中，31例患有原发性高血压，43例患有症状性高血压（40例为肾性，3例为肾上腺性）。在ⅠB期和ⅡA期高血压患者中，发现总代谢钠水平降低，尿排泄增加。在原发性高血压晚期，如同症状性肾性高血压一样，总代谢钠水平正常，或有轻微升高趋势。在肾上腺性高血压（康恩综合征、嗜铬细胞瘤）病例中，总代谢钠水平显著升高。总代谢钠水平与血浆及红细胞钠水平之间未见相关性。原发性高血压早期总代谢钠的降低必定是机体的一种适应性反应，这一点可由钠尿排泄增加得到证明。
