Lee D H, Goldberg A L
Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Trends Cell Biol. 1998 Oct;8(10):397-403. doi: 10.1016/s0962-8924(98)01346-4.
Proteasomes are major sites for protein degradation in eukaryotic cells. The recent identification of selective proteasome inhibitors has allowed a definition of the roles of the ubiquitin-proteasome pathway in various cellular processes, such as antigen presentation and the degradation of regulatory or membrane proteins. This review describes the actions of these inhibitors, how they can be used to investigate cellular responses, the functions of the proteasome demonstrated by such studies and their potential applications in the future.
蛋白酶体是真核细胞中蛋白质降解的主要场所。最近对选择性蛋白酶体抑制剂的鉴定，使得泛素-蛋白酶体途径在各种细胞过程中的作用得以明确，比如抗原呈递以及调节蛋白或膜蛋白的降解。本综述描述了这些抑制剂的作用、它们如何用于研究细胞反应、此类研究证明的蛋白酶体功能及其未来的潜在应用。
