Birchmeier C, Gherardi E
Dept of Medical Genetics, Max-Delbrück-Centrum for Molecular Medicine, Berlin, Germany.
Trends Cell Biol. 1998 Oct;8(10):404-10. doi: 10.1016/s0962-8924(98)01359-2.
A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such signals, known as hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in recent years because of its distinct structure, mechanism of activation and important roles throughout embryogenesis. This review discusses the main features of HGF/SF and its receptor, the product of the c-met protooncogene, and their role in embryogenesis.
许多涉及细胞迁移、生长或形态发生的发育过程都依赖于细胞外信号。一种提供此类信号的分子，即肝细胞生长因子/分散因子（HGF/SF），近年来因其独特的结构、激活机制以及在整个胚胎发育过程中的重要作用而备受关注。本文综述了HGF/SF及其受体（c-met原癌基因产物）的主要特征，以及它们在胚胎发育中的作用。
