Durán Reyes G, Gómez Meléndez M R, Hicks Gómez J J
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI.
Ginecol Obstet Mex. 1998 Sep;66:371-6.
The peroxidation products, the free radicals, and the antioxidants compounds notable increase during ovulation, implantation, and pregnancy evolution. Superoxide anion (O2-) rise six time more on the proestrous, than on other stages, while its regulation enzyme, the superoxide dismutase (SOD), decreases. The presence of superoxide anion is related with the edema and the cellular proliferation on the estrous. Superoxide anion is also connected with the increase of fluidity and polarity of the membranes during the implantation. As the pregnancy elapse the lipoperoxides products and the antioxidant compounds augment suggesting that lipoperoxides evoke defense mechanism in a way that, at the end of the pregnancy, the antioxidants exceed peroxidative phenomena. By the other hand, the nitric oxide radical has gained great importance during the pregnancy because it is considered one of the most powerful relaxants of smooth muscle. The inhibition of its synthesis provokes similar signs to the preeclampsia and tis administration can revert many vascular alterations. The role of free radicals is not limited to dangerous effects, but it also, in adequate concentrations, includes the as stimulators of grown factors, and participants of the membranes fluidity.
在排卵、着床和孕期过程中，过氧化产物、自由基和抗氧化化合物显著增加。超氧阴离子（O2-）在发情前期的含量比其他阶段高出六倍，而其调节酶超氧化物歧化酶（SOD）则减少。超氧阴离子的存在与发情期的水肿和细胞增殖有关。超氧阴离子还与着床期间细胞膜流动性和极性的增加有关。随着孕期进展，脂质过氧化产物和抗氧化化合物增加，这表明脂质过氧化以某种方式引发防御机制，在孕期结束时，抗氧化剂超过过氧化现象。另一方面，一氧化氮自由基在孕期变得非常重要，因为它被认为是平滑肌最强大的松弛剂之一。抑制其合成会引发类似先兆子痫的症状，而给予一氧化氮可以逆转许多血管改变。自由基的作用不仅限于危险影响，在适当浓度下，它还包括作为生长因子的刺激剂以及细胞膜流动性的参与者。
