Nohl F, Ferrari P
Departement Innere Medizin, Inselspital, Bern.
Ther Umsch. 1998 Sep;55(9):573-5.
A case report is presented, which describes a kidney-transplant recipient medicated simultaneously with both cyclosporin A and nifedipine and who developed an extreme form of gingival hyperplasia. Repeated dental-surgical treatments provided only temporary regression of the gingival overgrowth, however, after discontinuation of the calcium channel blocker there was a significant improvement of the hyperplasia that no longer required specific dental treatment. The prevalence and mechanisms of this side effect in solid-organ transplant recipients on cyclosporin therapy is discussed. Treatment consists in the discontinuation of potentiating factors like calcium channel blockers and possibly also a dose reduction of cyclosporin, which together may support or reduce the need of dental-surgical procedures.
本文报告了一例肾移植受者，该患者同时服用环孢素A和硝苯地平，出现了一种极端形式的牙龈增生。反复的牙科手术治疗仅使牙龈过度生长暂时消退，然而，停用钙通道阻滞剂后，增生有了显著改善，不再需要特殊的牙科治疗。文中讨论了实体器官移植受者接受环孢素治疗时这种副作用的发生率和机制。治疗方法包括停用像钙通道阻滞剂这样的增效因素，可能还需要减少环孢素的剂量，这两者共同作用可能支持或减少牙科手术的必要性。
