Csifó-Nagy Boróka, Hulik Emese, Zsoldos Géza Márton, Gera István
Semmelweis Egyetem, Parodontológiai Klinika, Budapest.
Fogorv Sz. 2013 Jun;106(2):61-70.
Gingival enlargement is a common form of periodontal tissue reaction to several irritating factors. The most common form is the drug related gingival hyperplasia--nevertheless the heredity gingival fibromatosis and hematological cases can also occur and might impose a challenge to periodontists. After a short literature summary three Case reports are presented. The first case is a drug related gingival overgrowth in a young kidney transplant women who took Cyclosporin-A. The excessive mass of fibrotic tissue was removed by a series of internal beveled incision and the oral and buccal gingival flaps were united with sutures. The healing was uneventful and during the follow up patient's compliance and oral hygiene was superb. The second case is a very severe antihypertensive drug related gingival overgrowth in a 62 years old man interfering with the closure of his lip and corrected with a combination of conventional gingivectomy and internal reverse beveled incision both and Ca-channel blockers. The third case is a 42 years old woman with chronic idiopathic hemolytic anemia who presented a sudden onset acute excessive generalized gingival enlargement accompanied with severe pain and fever. At admission she was suspect for leukemia. After obtaining biopsy samples and having negative histology the soft tissue mass was removed under general anesthesia with conventional gingivectomy technique, but after a couple of days the severe pain and gingival swelling recurred. With administering systemic corticosteroid therapy (32 mg Medrol), the gingiva healed in five days and the one year follow-up showed a stable hematological and periodontal status. Today the more conservative internal beveled incision is preferred over the conventional gingivectomy in the most cases because it provides a more predictable healing and better esthetics. The recurrence of the drug related gingival hyperplasia can be anticipated by meticulous postoperative individual oral hygiene and regular supportive therapy.
The combined conservative and surgical therapy leads to predictable postoperative result even in very severe systematically motivated gingival enlargements, nevertheless the successful patients management needs good cooperation with medical doctors and with the patients themselves.
牙龈增生是牙周组织对多种刺激因素常见的反应形式。最常见的是药物性牙龈增生,不过遗传性牙龈纤维瘤病和血液系统疾病也可能发生,这可能给牙周病医生带来挑战。在简短的文献综述之后,呈现三例病例报告。第一例是一名接受环孢素A治疗的年轻肾移植女性发生的药物性牙龈过度生长。通过一系列内斜切口切除过多的纤维化组织,将口腔和颊侧牙龈瓣缝合在一起。愈合过程顺利,随访期间患者的依从性和口腔卫生状况极佳。第二例是一名62岁男性因服用钙通道阻滞剂出现非常严重的抗高血压药物性牙龈过度生长,影响唇部闭合,采用传统牙龈切除术和内反斜切口联合治疗进行矫正。第三例是一名42岁患有慢性特发性溶血性贫血的女性,突然出现急性广泛性牙龈过度增生,并伴有严重疼痛和发热。入院时怀疑患有白血病。获取活检样本后组织学检查为阴性,在全身麻醉下采用传统牙龈切除术技术切除软组织肿块,但几天后严重疼痛和牙龈肿胀复发。给予全身皮质类固醇治疗(32毫克甲泼尼龙)后,牙龈在五天内愈合,一年随访显示血液学和牙周状况稳定。如今,在大多数情况下,相较于传统牙龈切除术,更倾向于采用更保守的内斜切口,因为它能提供更可预测的愈合和更好的美观效果。通过术后细致的个人口腔卫生和定期的支持性治疗,可以预期药物性牙龈增生的复发。
即使在因全身因素导致的非常严重的牙龈增生情况下,联合保守和手术治疗也能带来可预测的术后效果,不过成功的患者管理需要与医生以及患者自身良好合作。