Si Q M, Wu G C, Cao X D
National Laboratory of Medical Neurobiology, Shanghai Medical University, People's Republic of China.
Acupunct Electrother Res. 1998;23(2):117-24. doi: 10.3727/036012998816356562.
The present paper is to study the effects of electroacupuncture (EA) on acute ischemic stroke patient and acute cerebral ischemic rat. In clinic, 42 acute ischemic stroke patients were randomly divided into 2 therapeutic groups: drug group and EA+ drug group. Neurological deficits of patients were evaluated before and after the treatment by Chinese Stroke Scale. The results showed that the acute ischemic stroke patients treated by drug or EA+ drug were all partially recovered, but the clinical functional recovery in EA+ drug group was significantly better than in the drug group (P < 0.01). In laboratory, the model of reversible middle cerebral artery occlusion (MCAO) was used in rats. The somatosensory evoked potential (SEP) was recorded before and after MCAO. EA was applied one hour after cerebral ischemia and once a day after reperfusion for 7 days in EA+ MCAO group. It was shown that the amplitude of P1-N1 wave of SEP before MCAO was 100%. After MCAO 30 min the P1-N1 wave of SEP on the ipsilateral side of MCAO was decreased to 2.2 +/- 3% (MCAO group), 1.9 +/- 2% (MCAO+ EA group); and then recovered to 25.5 +/- 14.1% (MCAO group), 58.6 +/- 27.2% (MCAO+ EA group) after 7 days of reperfusion following MCAO 2 hours. The above results indicated that EA could promote the recovery of neurological function in acute ischemic stroke patients and SEP on MCAO rats.
本文旨在研究电针（EA）对急性缺血性脑卒中患者及急性脑缺血大鼠的影响。临床研究中，将42例急性缺血性脑卒中患者随机分为2个治疗组：药物组和电针+药物组。采用中国脑卒中量表在治疗前后评估患者的神经功能缺损情况。结果显示，药物组和电针+药物组的急性缺血性脑卒中患者均有部分恢复，但电针+药物组的临床功能恢复明显优于药物组（P<0.01）。在实验研究中，采用大鼠可逆性大脑中动脉闭塞（MCAO）模型。在MCAO前后记录体感诱发电位（SEP）。电针+MCAO组在脑缺血1小时后进行电针治疗，再灌注后每天1次，共7天。结果显示，MCAO前SEP的P1-N1波幅为100%。MCAO 30分钟后，MCAO同侧SEP的P1-N1波幅在MCAO组降至2.2±3%，在MCAO+电针组降至1.9±2%；MCAO 2小时后再灌注7天，MCAO组恢复至25.5±14.1%，MCAO+电针组恢复至58.6±27.2%。上述结果表明，电针可促进急性缺血性脑卒中患者神经功能及MCAO大鼠SEP的恢复。
