用卡维地洛治疗阿霉素诱导的心肌病。
Doxorubicin-induced cardiomyopathy treated with carvedilol.
作者信息
Fazio S, Palmieri E A, Ferravante B, Bonè F, Biondi B, Saccà L
机构信息
Department of Internal Medicine, Federico II University Medical School, Naples, Italy.
出版信息
Clin Cardiol. 1998 Oct;21(10):777-9. doi: 10.1002/clc.4960211017.
Abstract
Even today, heart failure due to doxorubicin-induced dilated cardiomyopathy seems to have a poor prognosis, as it is often irreversible and relatively unresponsive to standard medical treatment. This paper describes the first case of a patient complaining of severe symptoms of congestive heart failure due to doxorubicin-induced dilated cardiomyopathy unresponsive to standard medical treatment (digoxin, diuretics, and angiotensin-converting enzyme inhibitor), who showed complete clinical recovery and significant improvement of left ventricular dysfunction after carvedilol treatment. It also illustrates the possibility that carvedilol may be a first-choice drug for the treatment of this disease.
摘要
即使在今天，阿霉素诱导的扩张型心肌病所致的心力衰竭似乎预后不良，因为它往往是不可逆的，并且对标准药物治疗反应相对较差。本文描述了首例因阿霉素诱导的扩张型心肌病导致严重充血性心力衰竭症状且对标准药物治疗（地高辛、利尿剂和血管紧张素转换酶抑制剂）无反应的患者，该患者在卡维地洛治疗后临床完全康复且左心室功能障碍显著改善。本文还阐述了卡维地洛可能是治疗该病的首选药物的可能性。
相似文献
1
Doxorubicin-induced cardiomyopathy treated with carvedilol.用卡维地洛治疗阿霉素诱导的心肌病。
Clin Cardiol. 1998 Oct;21(10):777-9. doi: 10.1002/clc.4960211017.
2
Carvedilol in children with cardiomyopathy: 3-year experience at a single institution.卡维地洛用于儿童心肌病的单机构3年经验
J Heart Lung Transplant. 2004 Jul;23(7):832-8. doi: 10.1016/j.healun.2003.07.025.
3
4
The effect of carvedilol treatment on chronic heart failure in pediatric patients with dilated cardiomyopathy: a prospective, randomized-controlled study.卡维地洛治疗小儿扩张型心肌病慢性心力衰竭的效果：一项前瞻性随机对照研究。
Pediatr Cardiol. 2013 Mar;34(3):680-5. doi: 10.1007/s00246-012-0527-x. Epub 2012 Oct 30.
5
Effects of carvedilol on left ventricular function and oxidative stress in infants and children with idiopathic dilated cardiomyopathy: a 12-month, two-center, open-label study.卡维地洛对特发性扩张型心肌病婴幼儿左心室功能及氧化应激的影响：一项为期12个月的双中心开放标签研究。
Clin Ther. 2008 Apr;30(4):702-14. doi: 10.1016/j.clinthera.2008.04.007.
6
7
8
Effects of short- and long-term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy.短期和长期服用卡维地洛对特发性扩张型心肌病患者静息和运动时血流动力学变量、运动能力及临床状况的影响
J Am Coll Cardiol. 1994 Dec;24(7):1678-87. doi: 10.1016/0735-1097(94)90174-0.
9
Carvedilol as therapy in pediatric heart failure: an initial multicenter experience.卡维地洛用于小儿心力衰竭治疗：初步多中心经验
J Pediatr. 2001 Apr;138(4):505-11. doi: 10.1067/mpd.2001.113045.
10
Carvedilol therapy in pediatric patients with dilated cardiomyopathy.卡维地洛治疗小儿扩张型心肌病
Turk J Pediatr. 2009 Jan-Feb;51(1):22-7.
引用本文的文献
1
Unveiling the Complexities: Exploring Mechanisms of Anthracyclineinduced Cardiotoxicity.揭示复杂性：探索蒽环类药物诱导心脏毒性的机制
Curr Cardiol Rev. 2025;21(2):42-77. doi: 10.2174/011573403X322928241021100631.
2
Multiple mitochondria-targeted components screened from Sini decoction improved cardiac energetics and mitochondrial dysfunction to attenuate doxorubicin-induced cardiomyopathy.从四逆汤中筛选出的多种靶向线粒体成分可改善心脏能量代谢和线粒体功能障碍，从而减轻阿霉素诱导的心肌病。
Theranostics. 2023 Jan 1;13(2):510-530. doi: 10.7150/thno.80066. eCollection 2023.
3
Regulation of Transplanted Cell Homing by FGF1 and PDGFB after Doxorubicin Myocardial Injury.阿霉素心肌损伤后 FGF1 和 PDGFB 对移植细胞归巢的调节。
Cells. 2021 Nov 3;10(11):2998. doi: 10.3390/cells10112998.
4
Isorhapontigenin protects against doxorubicin-induced cardiotoxicity increasing YAP1 expression.异丹叶大黄素通过增加YAP1表达来预防阿霉素诱导的心脏毒性。
Acta Pharm Sin B. 2021 Mar;11(3):680-693. doi: 10.1016/j.apsb.2020.10.017. Epub 2020 Nov 1.
5
Cardiotoxicity of Anthracyclines.蒽环类药物的心脏毒性
Front Cardiovasc Med. 2020 Mar 18;7:26. doi: 10.3389/fcvm.2020.00026. eCollection 2020.
6
Liposomal Resveratrol and/or Carvedilol Attenuate Doxorubicin-Induced Cardiotoxicity by Modulating Inflammation, Oxidative Stress and S100A1 in Rats.脂质体白藜芦醇和/或卡维地洛通过调节大鼠的炎症、氧化应激和S100A1减轻阿霉素诱导的心脏毒性。
Antioxidants (Basel). 2020 Feb 16;9(2):159. doi: 10.3390/antiox9020159.
7
Recovery from left ventricular dysfunction was associated with the early introduction of heart failure medical treatment in cancer patients with anthracycline-induced cardiotoxicity.左心室功能障碍的恢复与癌症患者蒽环类药物诱导性心脏毒性的心力衰竭药物的早期引入有关。
Clin Res Cardiol. 2019 Jun;108(6):600-611. doi: 10.1007/s00392-018-1386-0. Epub 2018 Oct 26.
8
Cardio-oncology: Gaps in Knowledge, Goals, Advances, and Educational Efforts.心脏肿瘤学：知识差距、目标、进展与教育努力
Curr Oncol Rep. 2017 Aug;19(8):55. doi: 10.1007/s11912-017-0610-9.
9
Use of biomarkers for the assessment of chemotherapy-induced cardiac toxicity.生物标志物在评估化疗引起的心脏毒性中的应用。
Clin Biochem. 2015 Mar;48(4-5):223-35. doi: 10.1016/j.clinbiochem.2014.10.013. Epub 2014 Nov 7.
10
Cardiotoxicity in childhood cancer survivors: strategies for prevention and management.儿童癌症幸存者的心脏毒性：预防与管理策略
Future Cardiol. 2012 Jul;8(4):647-70. doi: 10.2217/fca.12.44.
本文引用的文献
1
The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group.卡维地洛对慢性心力衰竭患者发病率和死亡率的影响。美国卡维地洛心力衰竭研究组。
N Engl J Med. 1996 May 23;334(21):1349-55. doi: 10.1056/NEJM199605233342101.
2
Reversible doxorubicin-induced congestive heart failure.可逆性阿霉素诱导的充血性心力衰竭。
Arch Intern Med. 1982 Aug;142(8):1570-1.
3
The anthracycline antineoplastic drugs.蒽环类抗肿瘤药物。
N Engl J Med. 1981 Jul 16;305(3):139-53. doi: 10.1056/NEJM198107163050305.
4
Effect of anthracycline antibiotics on oxygen radical formation in rat heart.蒽环类抗生素对大鼠心脏氧自由基形成的影响。
Cancer Res. 1983 Feb;43(2):460-72.
5
Reversibility of severe left ventricular dysfunction due to doxorubicin cardiotoxicity. Report of three cases.阿霉素心脏毒性所致严重左心室功能障碍的可逆性。三例报告。
Ann Intern Med. 1987 Jun;106(6):814-6. doi: 10.7326/0003-4819-106-6-814.
6
Cardioprotective effects of carvedilol, a novel beta adrenoceptor antagonist with vasodilating properties, in anaesthetised minipigs: comparison with propranolol.卡维地洛（一种具有血管舒张特性的新型β肾上腺素能受体拮抗剂）对麻醉小型猪的心脏保护作用：与普萘洛尔的比较。
Cardiovasc Res. 1992 May;26(5):518-25. doi: 10.1093/cvr/26.5.518.
7
Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger.卡维地洛是一种新型血管扩张剂和β肾上腺素能受体拮抗剂，它也是一种抗氧化剂和自由基清除剂。
J Pharmacol Exp Ther. 1992 Oct;263(1):92-8.
8
Risk factors for doxorubicin-induced congestive heart failure.阿霉素诱导的充血性心力衰竭的危险因素。
Ann Intern Med. 1979 Nov;91(5):710-7. doi: 10.7326/0003-4819-91-5-710.
Zotero 插件