变构调节剂对毒蕈碱型乙酰胆碱受体结合特性及功能的积极作用。
Positive effects of allosteric modulators on the binding properties and the function of muscarinic acetylcholine receptors.
作者信息
Tucek S, Jakubík J, Dolezal V, el-Fakahany E E
机构信息
Institute of Physiology AV CR, Prague, Czech Republic.
出版信息
J Physiol Paris. 1998 Jun-Aug;92(3-4):241-3. doi: 10.1016/s0928-4257(98)80026-0.
PMID:9789816
Abstract
Data are reviewed indicating that allosteric modulators can enhance the affinities of muscarinic receptors for their antagonists and agonists, that the enhancement of the affinity for agonists is relevant functionally, and that the allosterically induced conformational change also affects the interaction between the receptors and the G proteins.
摘要
所审查的数据表明，变构调节剂可增强毒蕈碱受体对其拮抗剂和激动剂的亲和力，对激动剂亲和力的增强具有功能相关性，并且变构诱导的构象变化也会影响受体与G蛋白之间的相互作用。
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