线虫秀丽隐杆线虫中的四个乙酰胆碱酯酶基因。

Four acetylcholinesterase genes in the nematode Caenorhabditis elegans.

作者信息

Arpagaus M, Combes D, Culetto E, Grauso M, Fedon Y, Romani R, Toutant J P

机构信息

Groupe Cholinestérases, DCC-Inra, Montpellier, France.

出版信息

J Physiol Paris. 1998 Oct-Dec;92(5-6):363-7. doi: 10.1016/S0928-4257(99)80006-0.

DOI:10.1016/S0928-4257(99)80006-0

PMID:9789838

Abstract

Whereas a single gene encodes acetylcholinesterase (AChE) in vertebrates and most insect species, four distinct genes have been cloned and characterized in the nematode Caenorhabditis elegans. We found that ace-1 (mapped to chromosome X) is prominently expressed in muscle cells whereas ace-2 (located on chromosome I) is mainly expressed in neurons. Ace-x and ace-y genes are located in close proximity on chromosome II where they are separated by only a few hundred base pairs. The role of these two genes is still unknown.

摘要

在脊椎动物和大多数昆虫物种中，单个基因编码乙酰胆碱酯酶（AChE），而在秀丽隐杆线虫中，已克隆并鉴定出四个不同的基因。我们发现，ace-1（定位于X染色体）在肌肉细胞中显著表达，而ace-2（位于I染色体）主要在神经元中表达。Ace-x和ace-y基因在II染色体上紧密相邻，它们之间仅相隔几百个碱基对。这两个基因的作用仍然未知。