阿霉素对晚期肺癌体外作用的临床相关性
Clinical correlates of in vitro effect of adriamycin on advanced lung carcinoma.
作者信息
Mattern J, Kaufmann M, Wayss K, Volm M
出版信息
Klin Wochenschr. 1976 Jul 15;54(14):665-70. doi: 10.1007/BF01469146.
PMID:979067
Abstract
The effect of 1.38 X 10(-5) M adriamycin on tritiated uridine incorporation was studied after 3 hours treatment of suspensions of 25 advanced human lung carcinomas in vitro. The results were correlated with the responses to clinical therapy. All tumours which showed an inhibition of uridine incorporation in vitro of more than 40% were also sensitive to clinical treatment with adriamycin.
摘要
在体外对25例晚期人类肺癌的悬浮液进行3小时处理后，研究了1.38×10⁻⁵M阿霉素对氚标记尿苷掺入的影响。结果与临床治疗反应相关。所有在体外显示尿苷掺入抑制超过40%的肿瘤对阿霉素临床治疗也敏感。
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