Siregar P, Sinteff J P, Julen N, Le Beux P
Département d'Information Médicale, Université de Rennes I, Rennes Cedex, 35033, France.
Comput Biomed Res. 1998 Oct;31(5):323-47. doi: 10.1006/cbmr.1998.1485.
A 3D cellular anisotropic automata model with modifiable geometry is described. The modeling parameters include grain size, fiber orientation, and free-wall and septal thickness. From this modifiable model, three specific models corresponding to normal heart, left ventricular hypertrophy, and ventricular dilatation were generated. Each model is a conduction and propagation model in which the atria, the major atrial vessel bases, the ventricles, and the specialized conduction system are represented. Muscle tissues are modeled as bundles of fibers with anisotropic conduction speed of the activation wavefronts. Regional variations of conduction, refractory gradients, and regional potential gradients can also be specified before each simulation. Each element has adaptive properties with respect to cycle length and to the prematurity of incoming impulses. Action potentials can be specified for each cell and an equivalent source formulation is carried out to simulate the vectorcardiogram and the corresponding 12-standard-lead electrocardiogram.
描述了一种具有可修改几何形状的三维细胞各向异性自动机模型。建模参数包括晶粒尺寸、纤维取向以及游离壁和间隔厚度。从这个可修改模型中，生成了对应于正常心脏、左心室肥厚和心室扩张的三种特定模型。每个模型都是一个传导和传播模型，其中心房、主要心房血管基部、心室和特殊传导系统都有体现。肌肉组织被建模为具有激活波前各向异性传导速度的纤维束。在每次模拟之前，还可以指定传导的区域变化、不应期梯度和区域电位梯度。每个元件对于周期长度和传入冲动的提前期具有自适应特性。可以为每个细胞指定动作电位，并进行等效源公式化以模拟向量心电图和相应的12导联标准心电图。
