Horn K, Brehm G, Habermann J, Pickardt C R, Scriba P C
Klin Wochenschr. 1976 Oct 15;54(20):983-6. doi: 10.1007/BF01468949.
Continuous plasmapheresis with the IBM blood cell separator showed to be a successful therapy in a 26 year old patient with thyroid storm. The patient regained consciousness already during plasmapheresis whereby 5 liters of plasma were exchanged within 3.5 h. Although 633 mug thyroxine (T4) and 13.6 mug triiodothyronine (T3) were removed with the 51 plasma, no fall occurred in total serum T4 and T3 levels, probably due to the rapid reflux of thyroid hormones from the tissue into the intravascular space. Though total T4 and T3 did not change, there was a significant fall in free thyroid hormone levels documented by reduction of T3-uptake test and particularily of urine T4 and T3 excretion. These findings show that the elevation of thyroid hormone binding sites with donor plasma is even more important than the removal of thyroid hormones.
使用IBM血细胞分离机进行连续血浆置换，对一名26岁的甲状腺危象患者来说是一种成功的治疗方法。在血浆置换过程中，患者便已恢复意识，在3.5小时内置换了5升血浆。尽管通过这5升血浆清除了633微克甲状腺素（T4）和13.6微克三碘甲状腺原氨酸（T3），但血清总T4和T3水平并未下降，这可能是由于甲状腺激素从组织中迅速回流到血管内空间。虽然总T4和T3没有变化，但通过T3摄取试验的降低，尤其是尿T4和T3排泄量的降低，记录到游离甲状腺激素水平显著下降。这些发现表明，用供体血浆提高甲状腺激素结合位点比清除甲状腺激素更为重要。
