Tshirch L S, Drews J, Liedtke R, Schemmel K
Med Klin. 1975 May 2;70(18):807-11.
The conventional treatment of thyrotoxicosis is based on central and periphery therapeutic measures which respectively block the thyroid hormone production and subdue the hormone effect in the tissue. On account of long biological hal-life of thyroxine conventional methods of treatment fail to achieve a rapid reduction of the excessively high serumhormone level. As the overwhelming proportion of thyroid hormone is boud to serum proteins, plasmapheresis presents itself as a possibility of achieving this therapeutic aim. In the following a report is given on the successful practice of plasmapheresis in two cases of thyrotoxiicosis. In each of these, 1.4 and 1.2 litres of plasma respectively were re moved in all. Immediate combined use of plasmapheresis and conventional therapy appears to constitute a definite improvement in the treatment of thyrotoxicosis.
甲状腺毒症的传统治疗基于中枢和外周治疗措施，分别阻断甲状腺激素的产生并抑制组织中的激素作用。由于甲状腺素的生物半衰期长，传统治疗方法无法迅速降低过高的血清激素水平。由于绝大多数甲状腺激素与血清蛋白结合，血浆置换成为实现这一治疗目标的一种可能方法。以下是关于血浆置换在两例甲状腺毒症患者中成功应用的报告。在这两例患者中，分别总共去除了1.4升和1.2升血浆。血浆置换与传统疗法的立即联合应用似乎在甲状腺毒症的治疗中构成了一种明确的改进。
