Csiza C K, McMartin D N
Lab Anim Sci. 1976 Oct;26(5):781-7.
Dermatitis in a breeding colony of black (C57BL/6 Nya) mice was characterized by intense pruritus leading to self-mutilation and death. The cause appeared to be infestation with the mite, Myobia musculi. Ulceration of the skin resulted in exudation of serum proteins and exposure of the animals' immune defenses to microorganisms and irritants, with subsequent hyperplasia of regional lymph nodes and spleen. Affected mice had an increase in sessile plasma cells, serum immunoglobulin concentration, and percent of circulating granulocytes. The mites were eliminated by treatment with a dichlorvos-ronnel combination in liquid form, which was dispensed onto the bedding with an automatic syringe. The incidence of dermatitis was reduced to zero. Our experience with M musculi in two other strains of mice, both white, indicates that pathogenicity of this mite for mice varies according to the strain, sex, age, and individual differences in sensitivity of the mice as well as the mating ratios employed.
黑色（C57BL/6 Nya）小鼠繁殖群体中的皮炎表现为剧烈瘙痒，导致自残和死亡。病因似乎是感染了鼠肌螨。皮肤溃疡导致血清蛋白渗出，使动物的免疫防御暴露于微生物和刺激物中，随后区域淋巴结和脾脏增生。受影响的小鼠固有浆细胞、血清免疫球蛋白浓度和循环粒细胞百分比增加。通过用液体形式的敌敌畏 - 皮蝇磷组合进行治疗来消灭螨虫，该组合用自动注射器施用于垫料上。皮炎发病率降至零。我们在另外两种白色小鼠品系中对鼠肌螨的经验表明，这种螨虫对小鼠的致病性因小鼠的品系、性别、年龄、个体敏感性差异以及所采用的交配比例而异。
