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大肠杆菌O157:H7所致出血性结肠炎和溶血尿毒综合征

[Hemorrhagic colitis and hemolytic uremic syndrome caused by Escherichia coli O157:H7].

作者信息

Attar A, Becheur H, Gilbert T, Bloch F, Petite J P

机构信息

Service d'Hépato-Gastroentérologie, Hôpital Broussais, Paris.

出版信息

Ann Med Interne (Paris). 1998 Sep;149(5):288-90.

PMID:9791563
Abstract

We report the case of an Escherichia coli O157:H7 infection in a patient with hemorrhagic colitis. Initial diagnosis was ischemic colitis because of the age of the patient and clinical presentation. After one week, a hemolytic-uremic syndrome occurred and serologic antibodies to the lipopolysaccharide O157 of Escherichia coli O157:H7 were positive, leading to the diagnosis of hemorrhagic colitis caused by this bacteria. Escherichia coli O157:H7 colonic infection is not well known, specially in France where only two cases has been reported in adults. This bacteria and the toxin produced (Shiga-like toxin) should be searched in cultures of stools and colonic biopsies in case of bloody diarrhea, in particular when a hemolytic-uremic syndrome is associated. As clinical, pathological and endoscopic findings in Escherichia coli O157:H7-associated colitis may be similar to the ischemic colitis pattern, differential diagnosis may be difficult.

摘要

我们报告了一例患有出血性结肠炎的患者感染大肠杆菌O157:H7的病例。由于患者年龄及临床表现,最初诊断为缺血性结肠炎。一周后,发生了溶血尿毒综合征,并且针对大肠杆菌O157:H7脂多糖O157的血清学抗体呈阳性,从而确诊为由该细菌引起的出血性结肠炎。大肠杆菌O157:H7结肠感染并不为人熟知,特别是在法国,成人中仅报告过两例。在出现血性腹泻时,尤其是伴有溶血尿毒综合征时,应在粪便培养物和结肠活检中查找这种细菌及其产生的毒素(志贺样毒素)。由于大肠杆菌O157:H7相关性结肠炎的临床、病理和内镜检查结果可能与缺血性结肠炎模式相似,鉴别诊断可能会很困难。

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