Descamps P, Fondrinier E, Biquard F, Binelli C, Lepinard C, Loisel D, Crvencowitcz G, Platt L D, Karlan B Y
Service de Gynécologie-Obstétrique, CHU, Angers.
J Gynecol Obstet Biol Reprod (Paris). 1998 Sep;27(5):476-81.
Ovarian cancer is the most common cause of gynecologic cancer death, as most patients present with advanced disease, in which the prognosis is poor. Five year-survival is only 35% for all stages, while it exceeds 90% in stage I. Consequently, there has been heightened interest in the development of screening modalities that can detect ovarian cancer at an early stage to reduce the mortality of this disease. Unfortunately, transvaginal sonography and color Doppler imaging still have a high false positive rate and low specificity increasing the number of surgical procedures, even among women with a strong family history of ovarian cancer. Psychological impact and economical cost has also to be discussed when considering such programs.
卵巢癌是妇科癌症死亡的最常见原因,因为大多数患者就诊时已处于晚期疾病阶段,其预后较差。所有阶段的五年生存率仅为35%,而在I期则超过90%。因此,人们对开发能够早期检测卵巢癌以降低该疾病死亡率的筛查方法的兴趣日益浓厚。不幸的是,经阴道超声检查和彩色多普勒成像的假阳性率仍然很高,特异性较低,这增加了手术操作的数量,即使在有卵巢癌家族史的女性中也是如此。在考虑此类筛查项目时,还必须讨论其对心理的影响和经济成本。