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Effect of the MTHFRC677T variant on risk of venous thromboembolism: interaction with factor V Leiden and prothrombin (F2G20210A) mutations.

作者信息

Brown K, Luddington R, Baglin T

机构信息

Department of Haematology, Addenbrooke's NHS Trust, Cambridge.

出版信息

Br J Haematol. 1998 Oct;103(1):42-4. doi: 10.1046/j.1365-2141.1998.00935.x.

DOI:10.1046/j.1365-2141.1998.00935.x
PMID:9792287
Abstract

Odds ratios for the MTHFRC677T variant were determined in a large case-control study of 558 unselected patients with venous thromboembolism and 500 control subjects. The odds ratios for MTHFRC677T heterozygosity and homozygosity were 1.07 (95%CI 0.84-1.36) and 0.71 (95%CI 0.48-1.03). In patients with the factor V Leiden or the F2G20210A mutations there was no apparent increase in risk of venous thromboembolism due to the MTHFRC677T polymorphism. Thrombophilia testing should not include genotyping for the MTHFRC677T polymorphism.

摘要

相似文献

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The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin A20210 mutation.亚甲基四氢叶酸还原酶TT677基因型与静脉血栓形成相关，独立于FV Leiden和凝血酶原A20210突变的共存情况。
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