高血糖会降低胃泌素刺激的人类胃酸分泌。

Hyperglycaemia reduces gastrin-stimulated gastric acid secretion in humans.

作者信息

Lam W F, Masclee A A, De Boer S Y, Lamers C B

机构信息

Leiden University Medical Center, The Netherlands.

出版信息

Eur J Clin Invest. 1998 Oct;28(10):826-30. doi: 10.1046/j.1365-2362.1998.00362.x.

DOI:10.1046/j.1365-2362.1998.00362.x

PMID:9792996

Abstract

BACKGROUND

Recent studies have pointed to the role of plasma glucose in the regulation of gastrointestinal function.

METHODS

We have investigated the effect of acute hyperglycaemia on gastric acid secretion and pancreatic polypeptide (PP) release. Gastric acid output was measured under basal conditions and in response to intravenous infusion of gastrin-17 in two doses: 5 pmol kg-1 h for 60 min and 15 pmol kg-1 h for another 60 min. Seven healthy subjects were studied during normoglycaemia and during acute hyperglycaemia at 15 mmol L-1. Acid output was measured by continuous aspiration using phenol red as recovery marker. Plasma PP levels were determined at regular intervals.

RESULTS

Gastrin infusion at 5 pmol kg-1 h significantly (P < 0.05) increased acid output both during normoglycaemia and during hyperglycaemia. Gastrin infusion at 15 pmol kg-1 h further and significantly (P < 0.05) increased the acid output during both experiments. Hyperglycaemia significantly (P < 0. 05) reduced basal acid output (2.5 +/- 0.9 vs. 6.3 +/- 1.9 mmol h-1), low-dose gastrin stimulated acid output (6.5 +/- 1.7 vs. 13.0 +/- 1. 8 mmol h-1) and high-dose gastrin stimulated acid output (11.7 +/- 3. 0 vs. 19.4 +/- 3.0 mmol h-1) compared with normoglycaemia. Plasma PP levels were not stimulated by gastrin-17 infusion and were significantly (P < 0.05) reduced during hyperglycaemia.

CONCLUSIONS

(a) Basal and gastrin-17-stimulated gastric acid secretion are reduced during hyperglycaemia; (b) infusion of gastrin-17 to physiological post-prandial levels does not affect plasma PP levels; (c) plasma PP levels are reduced during hyperglycaemia, suggesting vagal-cholinergic inhibition of gastric acid secretion during hyperglycaemia.

摘要

背景

近期研究指出血浆葡萄糖在胃肠功能调节中的作用。

方法

我们研究了急性高血糖对胃酸分泌和胰多肽（PP）释放的影响。在基础条件下以及静脉输注两种剂量的胃泌素 -17 后测量胃酸分泌量：5 pmol kg⁻¹ h 持续 60 分钟，然后 15 pmol kg⁻¹ h 再持续 60 分钟。对 7 名健康受试者在血糖正常和血糖浓度为 15 mmol L⁻¹ 的急性高血糖状态下进行研究。使用酚红作为回收标记物通过连续抽吸测量胃酸分泌量。定期测定血浆 PP 水平。

结果

在血糖正常和高血糖状态下，以 5 pmol kg⁻¹ h 输注胃泌素均显著（P < 0.05）增加胃酸分泌量。在两个实验中，以 15 pmol kg⁻¹ h 输注胃泌素进一步且显著（P < 0.05）增加胃酸分泌量。与血糖正常相比，高血糖显著（P < 0.05）降低基础胃酸分泌量（2.5 ± 0.9 与 6.3 ± 1.9 mmol h⁻¹）、低剂量胃泌素刺激的胃酸分泌量（6.5 ± 1.7 与 13.0 ± 1.8 mmol h⁻¹）以及高剂量胃泌素刺激的胃酸分泌量（11.7 ± 3.0 与