Guccion J G, Patterson R H, Nayar R, Saini N B
Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA.
Ultrastruct Pathol. 1998 May-Jun;22(3):263-9. doi: 10.3109/01913129809033478.
A 45-year-old African American man presented with a small, solitary, nonulcerated cutaneous lesion of the right thigh of many years duration, which was excised. Light microscopically, the lesion consisted of an oval, well-circumscribed, intradermal proliferation of tubules, which were often dilated and lined by a double layer of tumor cells with conspicuous intraluminal papillations. Ultrastructurally, there was evidence of both intradermal eccrine duct and eccrine secretory coil differentiation. Although the majority of tumor cells resembled cells of the intradermal eccrine duct, occasional myoepithelial tumor cells and rare tumor cells having secretory granules and resembling dark mucous cells were indicative of eccrine secretory coil differentiation. The positive immunohistochemical staining for S-100 protein, CEA, EMA, and vimentin supported these ultrastructural findings.
一名45岁的非裔美国男性，其右大腿有一个持续多年的小而孤立、未溃疡的皮肤病变，该病变已被切除。光镜下，病变由椭圆形、边界清楚的真皮内小管增生构成，这些小管常扩张，内衬双层肿瘤细胞，管腔内有明显的乳头样突起。超微结构显示有真皮内小汗腺导管和小汗腺分泌蟠管分化的证据。虽然大多数肿瘤细胞类似于真皮内小汗腺导管的细胞，但偶尔的肌上皮肿瘤细胞和罕见的具有分泌颗粒且类似于暗黏液细胞的肿瘤细胞提示小汗腺分泌蟠管分化。S-100蛋白、癌胚抗原（CEA）、上皮膜抗原（EMA）和波形蛋白的免疫组化染色阳性支持了这些超微结构 findings。 （这里findings未翻译完整，原词应为发现结果等意思，结合前文推测是指超微结构发现的结果，由于没有完整的合适中文词汇，可根据实际情况调整，比如“这些超微结构发现” ）
