Mizuoka H, Senzaki H, Shikata N, Uemura Y, Tsubura A
Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan.
J Cutan Pathol. 1998 Jan;25(1):59-64. doi: 10.1111/j.1600-0560.1998.tb01691.x.
A case of papillary eccrine adenoma on the right forearm of a 78-year-old Japanese woman is reported. The tumor was 1.3 cm in diameter, occupying the whole thickness of the dermis. Histologically, the tumor was composed of dilated tubules of various sizes with intraluminal papillary projections, and was surrounded by a fibrous stroma. An immunohistochemical study revealed that the proliferating tubules were composed of a single outermost layer of alpha-smooth muscle actin- and keratin 14-positive myoepithelial cells, and keratin 8-positive inner cells. This antigen expression pattern was comparable to that of the normal eccrine secretory coil, which indicates that the tumor differentiated toward the secretory coil of an eccrine sweat gland.
报告了一例78岁日本女性右前臂的乳头状小汗腺腺瘤病例。肿瘤直径为1.3厘米，占据真皮全层。组织学上，肿瘤由大小各异的扩张小管组成，管腔内有乳头状突起，并被纤维性间质包绕。免疫组织化学研究显示，增殖的小管由最外层单一的α-平滑肌肌动蛋白和角蛋白14阳性的肌上皮细胞以及角蛋白8阳性的内层细胞组成。这种抗原表达模式与正常小汗腺分泌蟠管的模式相当，这表明肿瘤向小汗腺的分泌蟠管分化。
