Ermakovich I I
Lik Sprava. 1998 Jul-Aug(5):69-72.
In a study of 114 patients with ischemic heart disease (IHD) a relatedness has been found out of frequency and duration of "silent" ischemia of the myocardium to the degree of severity of atherosclerotic affection of the vascular bed and aggravation of IHD clinical symptomatology, with the activity of the opioid system tending to decline, catecholamines concentration being on the increase. It is beta-endorphin and leucine-enkephalin that have an important part to play in the regulation of algesthesia in IHD patients, the plasma content of which substances gets appreciably higher in exercise-induced painless ischemia. A change in the opioid-adrenosympathetic equilibrium is considered to be related to features of IHD clinical course. It is suggested that maintenance of the above two systems dynamic equilibrium might be of adaptive, antistressor character.
在一项针对114例缺血性心脏病（IHD）患者的研究中，已发现心肌“无症状”缺血的频率和持续时间与血管床动脉粥样硬化病变的严重程度以及IHD临床症状的加重相关，此时阿片系统的活性趋于下降，儿茶酚胺浓度则升高。β-内啡肽和亮氨酸脑啡肽在IHD患者痛觉调节中起重要作用，在运动诱发的无痛性缺血中，这些物质的血浆含量明显升高。阿片-肾上腺交感神经平衡的改变被认为与IHD临床病程特点有关。有人提出维持上述两个系统的动态平衡可能具有适应性、抗应激的特性。
