Sokolov E I, Zaev A P, Burmantova N P, Khovanskaia T P, Petrin S V, Filonov V K, Tebloev K I, Pereponov Iu P
Kardiologiia. 1992 Jul;32(7-8):32-5.
The specific features of responses of the sympathoadrenal system during its activation by graded exercise (E), including that along with anaprilin induced blockade of beta-adrenoceptors, were determined from the urinary excretion of norepinephrine, epinephrine, dopamine, and dioxyphenylalanine in 54 healthy males and 22 patients with postinfarction cardiosclerosis concurrent with Functional Class I-II angina pectoris on effort. E caused hyperreactivity of the sympathoadrenal system, as appeared as significantly greater increases in the levels of catecholamines and their precursors in the patients than in the healthy persons. A single anaprilin dose of 40 mg abolished the responsiveness to exercise and improved its tolerance. The revealed features of sympathoadrenal responsiveness to exercise with and without anaprilin suggest that the patients with coronary heart disease have sympathoadrenal dysfunction, which shows one of the possible mechanisms responsible for the cardioprotective effect of beta-adrenoblockers in this disease.
通过对54名健康男性和22名患有心肌梗死后心硬化并伴有I-II级劳力性心绞痛的患者进行分级运动（E）激活交感肾上腺系统时的反应特征进行了研究，这些特征包括在心得安诱导的β-肾上腺素能受体阻断的情况下，通过测定尿中去甲肾上腺素、肾上腺素、多巴胺和二羟苯丙氨酸的排泄量来确定。运动导致交感肾上腺系统反应过度，表现为患者体内儿茶酚胺及其前体水平的升高显著高于健康人。单次服用40毫克心得安可消除对运动的反应性并改善运动耐量。所揭示的有无心得安时交感肾上腺对运动反应的特征表明，冠心病患者存在交感肾上腺功能障碍，这显示了β-肾上腺素能阻滞剂在该疾病中具有心脏保护作用的一种可能机制。
