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氟米松诱导犊牛胰岛素抵抗。

Flumethasone-induced insulin resistance in calves.

作者信息

Sternbauer K, Luthman J, Jacobsson S O

机构信息

Faculty of Veterinary Medicine, Department of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.

出版信息

Zentralbl Veterinarmed A. 1998 Sep;45(6-7):441-3. doi: 10.1111/j.1439-0442.1998.tb00846.x.

DOI:10.1111/j.1439-0442.1998.tb00846.x
PMID:9793474
Abstract

The impact of one single therapeutic dose of flumethasone (0.5 mg/100 kg b.w.) on insulin sensitivity was studied in calves. Hyperinsulinemic, euglycemic clamp tests were performed before and after flumethasone treatment. At 24 h after treatment, insulin-dependent glucose utilization was reduced by 74% (P < 0.005). No significant changes occurred 72 h post-treatment.

摘要

研究了单次治疗剂量的氟米松(0.5毫克/100千克体重)对犊牛胰岛素敏感性的影响。在氟米松治疗前后进行了高胰岛素正常血糖钳夹试验。治疗后24小时,胰岛素依赖的葡萄糖利用率降低了74%(P<0.005)。治疗后72小时未发生显著变化。

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