氟米松诱导犊牛胰岛素抵抗。
Flumethasone-induced insulin resistance in calves.
作者信息
Sternbauer K, Luthman J, Jacobsson S O
机构信息
Faculty of Veterinary Medicine, Department of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
出版信息
Zentralbl Veterinarmed A. 1998 Sep;45(6-7):441-3. doi: 10.1111/j.1439-0442.1998.tb00846.x.
The impact of one single therapeutic dose of flumethasone (0.5 mg/100 kg b.w.) on insulin sensitivity was studied in calves. Hyperinsulinemic, euglycemic clamp tests were performed before and after flumethasone treatment. At 24 h after treatment, insulin-dependent glucose utilization was reduced by 74% (P < 0.005). No significant changes occurred 72 h post-treatment.
研究了单次治疗剂量的氟米松（0.5毫克/100千克体重）对犊牛胰岛素敏感性的影响。在氟米松治疗前后进行了高胰岛素正常血糖钳夹试验。治疗后24小时，胰岛素依赖的葡萄糖利用率降低了74%（P<0.005）。治疗后72小时未发生显著变化。
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