Ekström J
Department of Pharmacology, Göteborg University, Sweden.
Exp Physiol. 1998 Sep;83(5):697-700. doi: 10.1113/expphysiol.1998.sp004150.
Chewing and acid on the tongue evoked a flow of saliva from the duct-cannulated parotid gland of the conscious rat despite pretreatment with atropine and adrenoceptor antagonists. This non-adrenergic, non-cholinergic (NANC) response depended on an intact parasympathetic innervation and was abolished by a tachykinin antagonist. The present findings are consistent with a physiological role for the secretory NANC mechanisms of the salivary glands.
尽管事先使用了阿托品和肾上腺素能受体拮抗剂，但咀嚼和舌头上的酸仍能引起清醒大鼠腮腺导管插管后的唾液分泌。这种非肾上腺素能、非胆碱能（NANC）反应依赖于完整的副交感神经支配，并被速激肽拮抗剂消除。目前的研究结果与唾液腺分泌性NANC机制的生理作用一致。
